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Description

The pKa of the Cys 34 albumin thiol group is relatively low (~5) in comparison to the pKa of other low molecular weight aminothiols present in the plasma (8.5-8.9 for Cys and GSH, respectively) (105)

doi: 10.1084/jem.20182192 97 FischerTDWangCPadmanBSLazarouMYouleRJ

Glutathione (GSH, -glutamylcysteinylglycine) the most abundant, endogenous, intracellular antioxidant, could protect mitochondria from oxidative stress, whereas GSH deficiency accelerates the rate of aging and aging-related diseases