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The burden of proof lies with the complainant

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This study first demonstrated that TSA suppresses AF through dual modulation of prolonged post-repolarization refractoriness and conduction slowing, offering a novel therapeutic strategy for AF in patients with CHF

It is noteworthy that this regulatory system has a cross-dialogue with epigenetic mechanismsm 6 A modification can target the regulation of mRNA metabolism of genes associated with histone modification, suggesting that there is a collaborative regulatory network between the epigenome and the epigenome 151,152