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In the light of excellent performance of BBB crossing strategies for enhanced drug delivery, we will first summarize the structure and different cells contributing to the integrity of BBB (Fig

endophyticus Hbe603 contains a complete pathway of thirteen key enzymes, including myo-inositol 2-dehydrogenase, inosose dehydratase, glucuronate isomerases, 5-dehydro-2-deoxygluconokinase, 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase, methylmalonate-semialdehyde dehydrogenase and triosephosphate isomerase

SIN-TSL could release the drug efficiently and controllably at the RA rat hind limb for 48 h, extending the drugs half-life (159)

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