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Mass spectra were obtained on an ultrafleXtreme MALDITOF/TOF mass spectrometer equipped with a smartbeam solidstate laser (Bruker Daltonics) operating in the negative ion mode

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The essential feature of apoptosis is the release of cytochrome c from mitochondrial, regulated by the balance of between pro-apoptotic and antiapoptotic proteins in BCL-2 family, activation of initiator caspases (caspase 8, 9, and 10) and effector caspases (caspase 3, 6 and 7) [75]