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Finally, the types, locations, and stages of brain tumors, as well as the therapeutic regimen are also important factors to be considered to hypothesize the desired effect (pro/antioxidant) from an exogenous antioxidant in brain cancer treatment

All animal experiments were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and with the approval of the Institutional Animal Care and Use Committee of National Center of Biomedical Analysis

159 TTM may exert its anti-tumor effects by suppressing the transcriptional activity of NF-B, which in turn decreases the production and secretion of downstream angiogenic factors, such as VEGF and cytokines such as IL-1 and IL-8, thereby reducing angiogenesis

Increased lipid peroxidation and antioxidant activity in methionine-induced hepatitis in rabbits