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A key concept for understanding this interface is the model of allostasis (adaptation) and allostatic load (pathophysiology) [6] that we review below examining this model in relation to new insights from the recent work on the link between mitochondrial metabolism and epigenetic function to promote healthy behaviors and cognitive function

doi: 10.1186/s40168-017-0261-y 195 MachielsKJoossensMSabinoJDe PreterVArijsIEeckhautVet al

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demonstrated a relationship between high chemerin levels and functional disability in RA patients and found a correlation between functional disability and DAS-28