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Therefore, animal models could represent a more controlled and precise approach for isolating specific effects, particularly in studies focusing on aged muscle physiology

Intranasal naloxone administration

In addition to direct effects on ion channels, neurotransmitters may bind to G-protein coupled receptors, thereby eliciting cell-signaling effects that could result in metabolic changes (e.g., alterations in activity of various enzymes) within a postsynaptic cell (14)