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Oxidative stress plays a significant role in the development of cardiovascular diseases, including atherosclerosis and hypertension

it can be enzymatically detoxified or it reacts with proteins, transition metals or carbon dioxide ( 2 O 2 can be removed by the action of glutathione peroxidase (GPx), catalase (CAT), or peroxiredoxin, all of which convert it to water and oxygen ( 2 O 2 encounters a transition metal such as divalent iron (Fe 2+ ), it is non-enzymatically converted to the highly reactive hydroxyl radical (OH)

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