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Unlike conventional MR contrast agents, BRNPs release internal Mn 2+ in response to ROS stimulation, which allows for better display of ROS in the tumor and tumor microenvironment, thereby inducing T1-weighted MRI signal enhancement

Following this observation, they also show that recovering physiological levels of this modification by treatment with the histone deacetylase inhibitor SAHA restores the expression of learning-induced genes and the cognitive abilities of old mice