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First identified as a potential neuroprotective agent, in 2008, by researchers in Germany, [20] 9-me-BC was initially found to be of interest due to its ability to upregulate tyrosine hydroxylase, the enzyme responsible for converting the amino acid L-theanine into the dopamine precursor, L-DOPA

PdxCre mice) and orthotopic transplantation of KPC derived cells, MET inhibition with capmatinib sensitised PDAC tumours to gemcitabine, resulting in a reduction in primary tumour volume and metastatic burden via increased apoptosis [57]