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Patients who are good candidates typically have a visible groove or depression extending from the inner corner of the eye toward the midface, worsened by aging, weight loss, or genetic bone structure

The regulation of EGR1 on the expression of Nrf2 and HMOX1 was investigated through Western blot

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J Parkinsons Dis 9:603614 Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U (2000) Epidemiology of erectile dysfunction: results of the Cologne Male Survey. Int J Impot Res 12:305311 Brignole M, Moya A, de Lange FJ, Deharo JC, Elliott PM, Fanciulli A, Fedorowski A, Furlan R, Kenny RA, Martin A, Probst V, Reed MJ, Rice CP, Sutton R, Ungar A, van Dijk JG, Group ESCSD (2018) 2018 ESC Guidelines for the diagnosis and management of syncope