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Early evidence linking stress to hippocampal synaptic plasticity came from electrophysiological studies showing that intermittent tail shock during restraint significantly impaired LTP in the Schaffer collateral-commissural pathway to the cornu ammonis 1 (CA1) region in rat hippocampal slices ( Although chronically elevated cortisol is often considered detrimental, insufficient glucocorticoid signaling may also impair synaptic plasticity

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Its important to understand how cancer hijacks certain substances that we may think of as harmless, Harris said emphasizing that antioxidants can be a double-edged sword in some circumstances

Parallel microbial imbalance extends to respiratory ecosystems, where asthma severity correlates positively with reduced bacterial diversity and elevated proteobacterial abundance in the airway microbiome (Liao et al., 2022