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137 Although recent studies support a role for NLRP3 inflammasomes in APAP-induced liver injury, the discrepancies and complexity of available data underscore the need for further research

HPV promotes carcinogenesis through OS by various mechanisms, such as altering mitochondrial cristae, raising ROS levels and DNA damage by lowering the SOD 2 and GPx 1/2 antioxidant, activating the EGFR/MEK/ERK cell signaling pathway, and upregulating the OS sensor Pirin, and also causing LDHA translocation due to elevated ROS caused by HPV oncoprotein and subsequent methylation of histone H3K79

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