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Unlike traditional immunosuppressants, apremilast does not require routine liver function monitoring, as clinical studies have not shown a significant risk of hepatotoxicity

The medical record should highlight abnormal laboratory results, extreme vital sign variations, or severe gastrointestinal fluid losses

Furthermore, the patients with OIPN are more likely to benefit from duloxetine than patients with a paclitaxel-induced neuropathy based on an exploratory responder analysis [182], which suggests that action of duloxetines pharmacodynamic effect may be tightly associated with specific molecular mechanisms underlying OIPN [183, 184]

1160 Given that ROS are key contributors to cardiovascular damage, this property of perhexiline could have significant implications for the prevention and treatment of cardiovascular diseases