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Finally, existing challenges to brain drug delivery using nanoparticles are presented, such as the accumulation of nanoparticles in the brain, which can produce neurotoxicity, and the lack of preclinical CNS disease models that can mimic the microenvironment of the human brain relatively perfectly

Acknowledgements This work was partially supported by the Finish Line grant of Markey Cancer Center to H.S.Y as well as the Biostatistics and Bioinformatics, Biospecimen Procurement and Translational Pathology, and Flow Cytometry and Immune Monitoring Shared Resource facilities of the University of Kentucky Markey Cancer Center (P30CA177558)

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First, we wanted to shed light on the role of MRP1 in the fetal-directed MeHg transport