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TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA

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doi: 10.1016/j.jsbmb.2008.03.027 144 QureshiRPicon-RuizMAurrekoetxea-RodriguezINunes de PaivaVDAmicoMYoonHet al

The TGF- pathway is often dysregulated during aging, resulting in reduced collagen production, increased activity of extracellular matrix-degrading enzymes, and impaired cell regeneration