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The co-localization of Halo-Rac1 with EEA1 or Lamp1 progressively increased over time after EV addition in WT cells, but this increase was attenuated in CIP4 KO cells (Fig

By blocking FcRn-mediated IgG rescue from lysosomal degradation, these agents lower circulating pathogenic IgG autoantibody titers without broadly suppressing immune cells [26]