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Box A: Diversity of GPCR ligands Neurotransmitters norepinephrine adenosine histamine serotonin dopamine cannabinoids opiates acetylcholine GABA glutamate Peptide hormones endothelin glucagon angiotensin II GSH, FSH, CRH GnRH, ACTH Tastants, oderants, light Session Learning Objectives Learning objective 1

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However, says JoAnn Manson, chief of the division of preventive medicine at Brigham and Womens Hospital and the papers first author, Putting the risk into perspective, its the equivalent of the excess risk of breast cancer associated with drinking one to two alcoholic beverages daily. Across all age groups, bone fracture risks among hormone users was 33% lower as compared to the placebo group