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AGEs disrupt the dynamic balance of the skin (84), alter the normal substance composition and structure of different skin layers, impair the skin barrier function, and trigger skin issues

Increasing evidence indicates that CHE, as a benzophenanthridine alkaloid, exhibits its excellent anticancer activity as CHE can intervene in tumor progression and inhibit tumor growth in multiple ways, such as induction of cancer cell apoptosis, cell cycle arrest, prevention of tumor invasion and metastasis, autophagy-mediated cell death, bind selectively to telomeric G-quadruplex and strongly inhibit the telomerase activity through G-quadruplex stabilization, reactive oxygen species (ROS), mitogen-activated protein kinase (MAPK), and PKC

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development

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