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Previous work showed that AP can be activated under these conditions if the system includes copper, a redox-active transition metal with high affinity for sulfur atoms (Eben and Imlay, 2023)

James C.Y

Glutamatecysteine ligase (GCL) is the rate-limiting enzyme for glutathione synthesis, and knockout of the mouse Gcl gene is associated with embryonic lethality and increased risk of carcinogenesis (Yang et al