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The exact cause of PTLDS is not well understood, but it may involve a combination of factors such as an ongoing immune response, tissue damage from the initial infection, and possibly the presence of co-infections

This transformation happens primarily in the liver through a process called conjugation

Interestingly, Bottari and colleagues reported even higher circulating markers of oxidation (MDA and AOPP) after CHOP chemotherapy (cyclophosphamide, vincristine, doxorubicin, and prednisone) in dogs with multicentric lymphoma, suggesting that the treatment might exacerbate OS levels [74]

[PubMed] [Google Scholar] 44.Cerrahoglu K, Kunter E, Isitmangil T, Oztosun AI, Isitmangil G, Okutan O, et al