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Studies have shown that melatonin can improve the survival of cryopreserved spermatogonial stem cells (SSCs) by reducing ROS production during freezing and thawing (75)

doi: 10.1016/0304-3835(88)90010-9

A randomized (159), double-blind, placebo-controlled trial involving 46 adult SLE patients (23 in the synbiotic group, 23 in the placebo group) showed that 60 days of synbiotic supplementation significantly increased butyrate metabolism, reduced the pro-inflammatory cytokine IL-6, and inhibited the elevation of hs-CRP

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