glutathione redox luminescence The cycle illustrating the function of the two Glutathione redox cycle. Glutathione (GSH)

Mammalian cells contain six Prxs, classified into three groups: 2-Cys Prxs (Prx1-4), atypical 2-Cys Prx (Prx5), and 1-Cys Prx (Prx6)

Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]

Although C6 astroglioma cells recapitulates most of the features of astrocytes and represent a suitable model to evaluate oxidative stress-induced toxicity and resistance, these cells are deriving from tumors and they could thus acquire specific phenotype with regard to oxidative stress handling

Paclitaxel/methotrexate coloaded PLGA nanoparticles in glioblastoma treatment: Formulation development and in vitro antitumor activity evaluation