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The possibility of using the regulatory pathway of this mechanism with an indirect modulator, such as metformin, further enhances this potential

10.1038/embor.2012.156 54 KumarS.KaurA.ChattopadhyayB.BachhawatA

Such an understanding and the development of additional genetic and molecular tools to facilitate a combinatorial approach are critical next steps towards further facilitating mammalian hair cell regeneration