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confirmed no cytotoxicity to HaCaT keratinocytes or human dermal fibroblasts across a six-log concentration range (0.0058 to 5800 micromolar) 3

The silencing was consistent and reproducible 7 days post TRV inoculation and was observed in adults and nymphal stages feeding on the phloem of TRV plants expressing dsRNA for both genes (Figure 2, 1 week after silencing)

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The strong association between Alzheimer's disease (AD) and atherosclerosis in the Circle of Willis, the main arterial network that supplies the brain, is of great importance