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Larger, controlled studies are needed to validate these findings and assess their broader clinical applicability

While we used several markers (including SA--gal, lipofuscin, cyclin-dependent kinase inhibitors, SASP components and transcriptional senescence signatures) to characterize senescence in these models, we have to acknowledge the limitations of our study given the inherent heterogeneity of senescent cells

they are fellows and faculty members of the Seeds Scientific Research & Performance (SSRP) Institute , the global leader in cellular medicine and peptide research