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Potassium-competitive acid blockers have also been recently highlighted to limit the development of IBDs, such as colitis, which is often associated with the long-term use of PPIs

D-panthenol (vitamin B-5), allantoin, Purified (deionized) water, Aloe barbadensis

Various forms of gallbladder disease such as gallstones and gallbladder polyps are also common in those with PSC

Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit