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In reality, the human body tightly regulates blood pH between 7.35 and 7.45, and dietary bicarbonate has negligible influence on this system

One important caveat: wound serum from chronic wounds (such as diabetic ulcers) contains enzymes that break down GHK-Cu, which may limit topical efficacy on infected or chronic wounds

Given that this approach uses a selective ion pair technique, not a full scan technique like others, it can improve sensitivity by up to two orders of magnitude and the linear response over a wide dynamic range up to five orders of magnitude compared to full scan technique (Lange et al., 2008)

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