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Prolonged treatment further augmented myofiber regeneration, with treated mice showing increasingly larger fiber cross-sectional areas compared to untreated aged controls

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Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

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