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The antipsychotics associated with paralytic ileus include clozapine, quetiapine, olanzapine, and high potency antipsychotics.[] In addition, paralytic ileus is reported to be associated with the use of anticholinergic medications and tricyclic antidepressants.[] The risk factors for paralytic ileus include older age, female gender, higher daily dose of medication (clozapine), and concomitant use of opioids.[] Among all the antipsychotics, gut hypomotility with clozapine has received significant research attention and this has been attributed to the anti-muscarinic effects, anti-adrenergic effects, and anti-serotonergic effects of clozapine

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American Parkinson Disease Association, Inc