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Cristian Nelson Hear From Our Students & Families

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate