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Three days later, mice received oral gavage of metformin at 150 mg/kg followed by injection of STF-31

When deciding which solubility tag to use, it will be worth thinking carefully about the characteristics of the protein you are purifying, and which downstream applications you have in mind

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102, 103, 104 Other plasma membrane transporters have been suggested to contribute to the extrusion of CDDP (hence promoting CDDP resistance in preclinical as well as clinical settings), notably ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (ABCC2), best known as multidrug resistance-associated protein 2 (MRP2) 105, 106, 107, 108, 109 and ATPase, class VI, type 11B (ATP11B)