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Additionally, curcumin actively inhibits COX-2 (cyclooxygenase-2) and LOX (lipoxygenase), the specific inflammatory enzymes that over-the-counter NSAIDs target to reduce pain and swelling, providing natural, systemic relief without the gastrointestinal toxicity associated with long-term NSAID use

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Originally, BPC 157 appears as a cytoprotective antiulcer peptide, stable in human gastric juice, previously employed in ulcerative colitis clinical trials and now in those concerning multiple sclerosis (Sikiric et al., 1993