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Introduction Branched-chain amino acids (BCAAs) comprise three essential amino acids, leucine, isoleucine, and valine, which all have multiple functions in the brain (Yudkoff, Figure 1), ultimately yielding acetyl coenzyme A (CoA) or succinyl CoA (Sperringer et al., Figure 1 Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by a heterogeneous pathology comprising defective protein clearance (Braak and Braak, de novo synthesized (Sperringer et al., The goals of this study were to perform the first functional profiling of BCAA metabolism in human astrocytes and identify metabolic alterations in BCAA metabolism in the pathophysiology of AD using human induced pluripotent stem cell-derived astrocytes and neurons

Its use leads to increased endurance, improved heart function, increased muscle mass by accelerating metabolic processes in cells, improving the penetration of vitamins, minerals and excretion of breakdown products, reducing the risk of fatty liver disease

doi: 10.3389/fmicb.2019.00829 81 TombolaFCampelloSDe LucaLRuggieroPDel GiudiceGPapiniEet al

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