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stimulated KGN cells with the follicular fluid from women with PCOS and found that it activated NLRP3 inflammasomes, the NF-B pathway, and impaired mitochondria structure and function in KGN cells were found [107]

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Even though preclinical research data suggest that total CD44 play a significant role in the chemoresistance of cancer patients, there is a limited amount of conducted clinical studies regarding total CD44 targeted therapies (Table 5)