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Acknowledgements We would like to thank the Laboratory of Hematology (GIGA-ULige), the Centre for Protein Engineering (ULige) and the Molecular Imaging and Therapy Laboratory (Vrije Universiteit Brussel) for their excellent technical assistance in our different projects

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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver