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Together, impaired viral clearance, low levels of type I interferons in the initial stage of infection, increased neutrophil extracellular traps and triggered NK cell activation constitute the plausible predisposing factors that drive the cytokine storm or cytokine storm syndrome in COVID-19 contributing to the aggressive inflammatory response

Xiaoning Li and colleagues have demonstrated that T-bet functions as a transcriptional activator that directly enhances the expression of gonadotropin-releasing hormone 1 (Gnrh1) by binding to its promoter region

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