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Epoxy can linings are a major BPA (bisphenol A, a synthetic compound used in many plastics and coatings) source, and this overlaps with broader plastic contact reduction

[9] The mature protein is highly stable, [10] but unstable when in its metal-free and disulfide-reduced forms

By contrast, the inhibition of sirtuin (Sirt)3 activates the NF-B signaling pathway, leading to worsening vascular inflammation, reduced NO production, increased ROS levels and decreased levels of L-arginine, further deteriorating vascular lesions (36)