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As Gpx4 requires glutathione as a substrate, ferroptosis is also induced by disruption of glutathione supply via inhibition of glutathione synthesis (e expression is critical to protection against acute lung injury in mice

Using a Cre-inducible viral vector system to overexpress SIRT1 selectively in dopamine D1 or D2 subpopulations of medium spiny neurons (MSNs) in the NAc indicated that SIRT1 promotes depressive-like behaviors only when overexpressed in D1 MSNs, with no effect seen in D2 MSNs

Systemic chemotherapeutic agents, particularly cyclophosphamide (CPX) and other nitrogen mustard alkylating agents, cause severe clinical manifestations such as cystitis (102)