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The two enzymes, phenylalanine ammonia-lyase 1 (PAL1) and isochorismate synthase 1 (ICS1), are the key enzymes in the SA synthesis pathway

Although the thyroid gland is not the organ that has the most significant overall amount of Se in the human body, it does have the highest concentration of Se among all endocrine organs and, in fact, among all tissues regarding the amount of Se that it contains per gram [9]