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The expression levels of important genes in cumulus cells, such as IGFBP2, BMP15, GDF9, HAS2, and STAT3, were noticeably greater in COCs treated with heat stress-derived EVs than in those exposed to EVs from cows kept in thermo-neutral circumstances

One study of post-mortem ChAT activity found that lower ChAT activity in AD patients was associated with significantly lower previous scores on the Mattis Dementia Rating Scale and the Mini-Mental State Examination, especially in the graphomotor/praxis, attention/registration, and recent memory scores (60)