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Recent evidence highlights that sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as canagliflozin, attenuates VC in CKD rats by suppressing NLRP3-mediated cytokine release, suggesting a therapeutic avenue (59)

Author contributions BH: data curation, formal analysis, project administration, supervision, writingoriginal draft, and writingreview and editing

The study of nuclear compartmentalization of GSH poses a significant methodological challenge and the findings were controversial over the last decade

[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness