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For lower doses its more uncertain but there is a potential benefit to taking them with food

McDermott has led randomized clinical trials to identify innovative therapies to improve functional performance and prevent mobility loss in people with PAD

All data supporting the findings of this study are available within the paper and its supplemental material

However, conditions affecting the gastrointestinal tractincluding pernicious anaemia, Crohn's disease, coeliac disease, or gastric surgerycan significantly impair absorption, necessitating alternative supplementation routes such as intramuscular hydroxocobalamin injections, which deliver B12 directly into the bloodstream