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Pyroglutamic acid (5-oxoproline), a glutamate cyclized derivative, also presented a higher abundance in OVX rat serum/urine samples that was significantly reversed by HPL therapy (Figure 3D, metabolite determination results are shown in Supplementary Tables S10)

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Similar to DN-RAGE, sRAGE has no intracellular signaling tail, but also does not have the transmembrane domain, thus it is circulating protein

Sodium and calcium: Consume a diet that contains moderate amounts of sodium, not exceeding adequate intake recommendations