l carnitine role transporting fatty acids into mitochondria Shuttle l carnitine fatty acid transport

doi: 10.1001/jama.2020.12839 21

For example, doxorubicin (DOX) has cardiac side effects that lead to irreversible dilated cardiomyopathy and congestive heart failure, and acetylcarnitine has been shown to prevent cardiac functional and structural damage caused by DOX-induced oxidative stress [289]

The hydrophobic tail of LCACs can be inserted into the membrane and may trigger the nonspecific activation of signaling pathways in the inner mitochondrial membrane to modulate its function, providing new insights into the unique mechanism of action of acylcarnitines in mitochondrial homeostasis [25]

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