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Under physiological conditions, it supports synaptic plasticity [346], whereas under pathological states, such as during astrocytic necroptosis, proBDNF may exert neurotoxic effects and promote apoptotic signaling [349]

Maintenance of SOX9 stability and ECM homeostasis by selenium-sensitive PRMT5 in cartilage

Outcome measures include biomechanical testing (load to failure, stiffness), histological scoring (collagen organization, fibroblast density), and functional assessment (gait analysis, range of motion)

On gross examination, the smaller kidney was dark red in color with an uneven surface, and the capsule could be easily removed (Figure 1B)