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It was noteworthy that oral L-theanine could also weaken the adverse reactions of S-1 adjuvant chemotherapy (75)

Moreover, reactive toxic aldehydes among lipid peroxidation products such as 4-hydroxy-2-nonenal (4-HNE) or malondialdehyde (MDA) are confirmed as markers of oxidative stress-induced lipid peroxidation [17, 18]

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The MYC protein, which regulates both cell proliferation and chemoresistance in various cancers 39,40 , was expressed at high levels in the tumor and stromal compartments of the chemo-sensitive patients in the AMC NAC cohort