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4.3 Antioxidation OS plays a critical role in the progression from simple steatosis to steatohepatitis and fibrosis in MASLD

Specifically, SOD converts superoxide radicals (O 2 ) into H 2 O 2 , which is then broken down by CAT into water and oxygen, preventing oxidative damage [23]

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Once absorbed through the gastrointestinal tract, respiratory system, or skin, arsenic enters systemic circulation predominantly by binding to erythrocytes and subsequently accumulates in organs such as the liver, kidneys, lungs, spleen, and keratin-rich tissues such as the skin and hair