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The association between cytoplasmic pattern recognition receptor nucleotide-binding oligomerization domain 2 (NOD2) and the pathogenesis of intestinal diseases has been established (Watanabe et al., 2006

Site-directed mutations of AC5 in the presence of other divalent cations indicate that the Mg 2+ -binding loci at the AC5 catalytic site are essential for its Ca 2+ -mediated inhibition (Hu et al., 2002

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