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and their induced urolithin C dehydroxylase operon are primary contributors to UA biosynthesis (17)

Both chemical groups were identified and present in Hericium erinaceus ( H

Although gene amplification has been studied most extensively in relation to methotrexate resistance, there is increasing evidence for the importance of this mechanism in determining resistance to several other drugs, including upregulation of the target enzyme for the active metabolite of 5-FU (thymidylate synthetase) (Watson et al, 2010)